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Untangling G-Quadruplexes in DNA: The Effects of Nucleotide Excision Repair
Jaidelin Alvardo, Abiageal Riley, Erick Morales Orrante, and Raynne Malik
Nucleotide Excision Repair (NER) remo ves bulky DNA lesions that are attributed to UV irradiation, environmental mutagens, and chemo-therapeutic agents (Schärer, CSH Perspectives Biology, 2013). G4- quadruplexes are formed by four guanines hydrogen bonded together to form a planar ring, and stacking of the hydrophobic G quartets stabilizes the quadruplex structure Capra et al.,PLoS Computational Biology, 2010). A surplus of this structure is linked to genomic Instability and cancer development.
Prior studies indicate that because NER eliminates large lesions of DNA, there may be a link to the removal of G4-quadruplexes through Nucleotide Excision Repair (De Magis et al, Nature,2020). Dr. Alexandra Berroyer's research on human cells was applied to this experiment to test if NER-deficient yeast is more sensitive to treatment with G4-binding drugs than in NER-proficient yeast. We hypothesize that NER removes G-quadruplexes from DNA and prevents DNA damage caused by them, which in turn causes NER deficient yeast to display an increased sensitivity to G4-binding drugs.
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Chasing the Enslaved, Not Justice: Rangers of Oppression
MacKenzie Arendall
01. Introduction: Rangers Policed & Profited in Slavery The Underground Railroad did not lead only north. It also led south into Mexico, where slavery had been abolished since 1829. Enslaved Texans risked the perilous journey, hundreds of miles, across unforgiving terrain. Even more dangerous than the harsh elements were the slavecatchers. Enslavers offered generous bounties, advertised in newspapers, for the recapture of their human “property.” Among the slavecatchers profiting from and policing slavery were many members of the infamous Texas Rangers. The Texas Rangers have been commemorated for heroism on the western frontier and honored for upholding the law and protecting growing settlements. However, this narrative obscures the reality of the Rangers. They also participated in, and profited from, slavery in Texas. Their largest role was capturing (and sometimes killing) runaways. Beyond slavecatching, they served several other roles: as slave jailors and sellers, and as illegal raiders into Mexico to recapture Blacks granted sanctuary. A few Rangers even enslaved Black Texans themselves. This research challenges the portrayal of the Texas Rangers as valiant heroes by examining their major commitment to policing slavery and profiting personally from it. This analysis of documented cases of Texas Rangers pursuing runaway slaves has uncovered the dual nature of these frontier legends and argues for a more complete and critical understanding of their legacy.
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From Ideas to Impact: Evaluating How Financial Technology Expands Financial Inclusion Across Countries
Shravani Atakari
Financial inclusion refers to access and use of financial services (World Bank, 2022). Traditional finance excludes users due to:
• High costs • Geographic distance • Limited credit History . Fintech expands access through digital tools Purpose: Analyze how fintech improves inclusion and what drives adoption
Research Questions How does financial technology reduce barriers to financial inclusion, and what factors influence its adoption among underserved populations? Objectives Identify key barriers to financial inclusion Analyze how fintech reduces these barriers Examine adoption factors (TAM + UTAUT) Propose solutions to improve adoption
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Contrast Therapy is Associated with Higher Thermal Comfort for a Similar Acute Inflammatory Response Compared with Sauna Therapy
Rene Barbier, Benjamin Enslow, Jace Nicolet, Louis Hein, Kelvin Wu, and Sven Hoekstra
Passive heat therapy, through sauna or hot water immersion, can improve cardiometabolic health outcomes. An increasingly popular thermal modality is contrast therapy, during which sauna therapy is interspersed with cold exposure. However, the acute physiological and perceptual responses to contras therapy in comparison with traditional sauna remains unknown. This study compared the acute inflammatory, physiological, and perceptual responses to contras against heat therapy in predominantly young, healthy individuals
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Impact of Liver-Secreted Small Extracellular Vesicles on Myotube Funcation
Tatiana Barrantes, Ioannis Tsialtas, Qing Zhang, and Kevin Koronowski
Extracellular vesicles (EVs) mediate intercellular communication by transferring molecular signals between tissues. Liver-derived EVs contribute to metabolic regulation and have been implicated in tissue cross-talk during health and disease. Skeletal muscle is a highly metabolic tissue that depends on mitochondrial respiration for energy production. However, whether liver-secreted EVs influence myotube mitochondrial function remains unclear. Here, we investigate the impact of liver-derived EVs on myotube mitochondrial respiration.
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Mica Productions: The Sad Truth Behind Cosmetic Corporations' Impact on Children's Well-being in India
Nyleen Beavides
Mica is a shiny silicate mineral found in granite, crystals, or rocks. This mineral has attracted the eyes of many cosmetic corporations. Due to high rates of unemployment and poverty in Asian countries, particularly in India’s Jharkhand region, corporations have taken over to profit the exportations of mica. India relies on illegal child labor in mica mining sites that are not only hazardous to children, but the economy and ecosystem. Previous research has shown how cosmetic corporations use mica as one of their main ingredients for shiny pigmentations within their products. However, there is limited research that has indicated the links between child labor and the cosmetic industry. This research examines the effects that cosmetic corporations have on children in India. Specifically, it discusses why the high demand of mica increases child labor and negatively impacts the health, economic, and social well-being of children. By analyzing secondary sources such as peer reviewed articles, reports, and policies in India, this study contributes to a better understanding of exploitative child labor by cosmetic corporations.
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U.S Sanctions in Venezuela: The Jeopardication of International Human Security and Economic Stability
Nyleen Beavides
Enforced in 2005, the U.S sanctions in Venezuela were the first form of restrictive mechanisms for the perspective outcome of reducing human right abuses, antidemocratic action, and corruption. Since then, the United States has imposed several sanctions on the Venezuela government to which it has enforced the idea of whether it takes corruption to fight corruption. While imposed U.S sanctions on Venezuela were intended to pressure the Maduro government into democratic reform without corruption and human rights violation over the region, these sanctions have done more harm on Venezuelan citizens rather than help them. The initial purpose of sanctions are designed to isolate an economy in order to force compliance. This research investigates whether United States sanctions have jeopardized the fundamental economic rights and human security of Venezuelan citizens to pressure the Maduro government into democratic reform. This paper questions whether the internal economic mismanagement and jeopardization of human rights contributed to Venezuela’s instability are caused by the interference of the United States government. Specifically, it seeks to discuss how the problem is not simply about the restriction on the Maduro government operations and systems, but the restriction of human security and economic rights to Venezuelan citizens. This study argues whether the United States government has violated the principles of International Law such as the OAS charter and UN Charter. By analyzing, the economic and political effects of U.S sanctions on Venezuela, this paper examines how rather than producing regime change, it has pushed the Venezuelan regime towards greater authoritarian control, deeper political and economic suppression, and increased humanitarian crisis.
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Social Media Microtrends and the Economic Realities of Young Consumers
Camila Berumen
This study expects to reveal how social media microtrends act as indicators of the economic realities' young consumers experience, including financial pressure, shifting spending habits, and changing values around consumption. By analyzing how these realities are expressed through digital trends, the research will provide a deeper understanding of how economic conditions are communicated in everyday online behavior. This research addresses the issue that traditional economic measures often overlook lived experience, especially among younger generations. By focusing on microtrends, the study offers a more nuanced and accessible way to understand how economic realities are felt and expressed, rather than just measured. The study will build on existing knowledge in communication studies by connecting digital media practices with economic meaning making. It opens opportunities for further research on how online culture reflects broader social and economic conditions. Additionally, it can contribute to social awareness by highlighting the financial challenges young consumers face, encouraging more inclusive conversations about economic inequality. By recognizing social media as a space where economic realities are shared and interpreted, this research also supports greater participation in understanding and discussing financial experiences.
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Healthcare Systems & Policy Implications for Tele-Dentistry Policies on access to Dental Care for underserved populations in the United States
Deeya Bhadresa
Access to dental care remains a significant public health challenge for people in rural and low-income communities. Tele dentistry has shown the ability to expand preventive services, improve care coordination, and reduce geographic barriers. However, inconsistent Medicaid coverage, limited infrastructure, and low provider participation restrict its impact. The main recommendation is standardizing Medicaid tele dentistry coverage and reimbursement across states to improve access and equity. Action is needed now to preserve post–COVID-19 telehealth gains and address persistent oral health disparities.
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America First: U.S Justification for Intervention in Latin America
Lenardo Buentello
In November 2025, the United States released a new National Security Strategy that strongly focuses on securing key resources before rival countries, especially in the Western Hemisphere. This approach is like policies like the Monroe Doctrine, which emphasized U.S. influence in the region. This strategy is already being put into action in Venezuela, where U.S. forces captured President Nicolás Maduro and his wife on drug trafficking charges. These actions reflect the strategy’s focus on national security and resource control. Many countries question whether the U.S. acted legally and argue that it ignored international norms. Latin America has become a region of growing competition, with countries like China, Russia, and Iran increasing their presence. For example, China invested over $160 billion in the region between 2000 and 2020, focusing on long-term partnerships. U.S. actions in Venezuela could set a risky precedent. Other countries may feel justified in ignoring international law and national sovereignty in similar ways. This analysis examines how the 2025 National Security Strategy is being used to justify U.S. intervention and how these actions may affect Venezuelan citizens. The people of Venezuela are the most vulnerable, as they have little control over these decisions but will face the consequences. Past U.S. interventions in Latin America show that such actions can sometimes create more harm than good. Overall, the strategy appears to expand older interventionist ideas to justify involvement in Venezuela under the goal of national security, with significant potential impacts on both international norms and everyday life in Venezuela.
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Artificial Intelligence and the Future of Global Inequality
Valentina Caceres
Artificial Intelligence (AI) is rapidly becoming a central tool in the global system, shaping economic growth, political power, and international influence. While AI is often celebrated for innovation and progress in different sectors like education, healthcare, security and more, its development is uneven and mostly concentrated in wealthy countries. Because AI is increasingly embedded in economic production, public administration, and social services, access to AI capabilities has become a key determinant of global competitiveness and influence. Many developing nations lack the capital, infrastructure, and technological capacity needed to compete in the global economy driven by AI. This imbalance matters because it risks reinforcing global inequalities, affecting access to education, healthcare, and economic opportunity, and reshaping global influence around technological dominance rather than cooperation. Many countries in the Global South face limited access to capital, infrastructure, and technological capacity, restricting their ability to participate in digital economy. Rather than reducing inequality, AI may reinforce existing global disparities by concentrating technological power, data, and opportunities in the Global North. This project examines how AI development, shaped by techno-nationalist priorities such as security and competitiveness, contributes to global inequality and limits opportunities for inclusive development, particularly in areas like education, healthcare, and economic growth.
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The relationship between environmental cues and emotional responses
Isbella Cantrell, Ashley Frost, and Mark Sanchez
The purpose of this study was to better understand if the environment influenced an individual’s emotions by observing horror and non-horror video games and coding the frequency of observed reactions. Former research illustrates that emotional arousal during video games may activate defensive behaviors similar to real-life threats. Three different YouTube streamers were observed playing one horror and two non-horror video games. All three streamers played the same three games. It was expected that all three players would have more frequent reactions to horror games as opposed to non-horror games (H1), that anger reactions would occur more frequently than sympathetic reactions among the non-horror group (H2), and that isolated vocalizations would occur more frequently across all conditions (H3). Participants were observed playing each game, their emotional reactions were recorded and categorized into three different classifications: isolated vocalizations, isolated physical reactions, and a combination of both. An independent samples t-test was utilized to analyze H1, a one-sample t-test for H2, and a one-way ANOVA with Post hoc LSD was utilized to analyze H3. Results indicated no statistically significant difference in the frequency of horror games compared to non-horror games. It was statistically significant that anger was the most common emotional response, and that vocalizations were the predominant reaction type across all games. Findings suggest that emotional arousal is likely less dependent on game genre and more dependent on neural network pathways. Future studies should look at the intensity of emotional reactions, utilize biometric data alongside observations, and measure different emotions across different video game genres.
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Comparing Head Shape of Polymorphic Subterranean E. latitans and Subterranean E. sp. 4
Brandon Chapa, Jordan Cosgrove, and Lizzeth Holguin
Eurycea latitans (E. latitans) from Honey Creek Cave and unnamed Eurycea species from New Braunfels, Texas (E. sp. 4) are two paedomorphic subterranean species. E. latitans is polymorphic, meaning it also exists as a surface species. Similarities in morphology of subterranean salamander species may be due to convergent evolution as a result of living in similar environments. These similarities include having flatter, wider heads, and wider mouths than surface species (Tovar et al. 2025). Variation may also exist among different subterranean salamander species. Texas Eurycea salamanders display “complex patterns of morphological divergence”, suggesting that isolation and local environmental pressures can drive morphological change (Devvitt et al, 2013). E. latitans may also show some variance from E. sp. 4 due to a more recent surface species ancestor or due to more phenotypic variability. Polymorphic species may exhibit greater variability in phenotype than monomorphic species (Takahashi and Noriyuki 2019). We expect there to be morphological differences in the head shapes of E. latitans and E. sp. 4.
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The Missing Lynx: Ivestigating passive and active rewilding with the Eurasian lynx
Isaiah Charles, Tatiana Flores, and Isabella Lopez
The Eurasian Lynx (Lynx lynx) is a wild cat native to the boreal forests, mountains and grasslands of Europe and Asia (Bhattacharyya, 2025). The Eurasian lynx keep ungulate populations in check which allow for forests to recover from overgrazing, promoting biodiversity and ecological balance. However, the Eurasian lynx had become locally extinct across Europe by the 1900s due to habitat loss, hunting by farmers in retaliation for predation of livestock and the illegal fur trade. Conservation and ecological restoration efforts to rebuild the lynx population have been underway. Rewilding is a form of ecological restoration involving the reintroduction of a species to increase biodiversity and restore natural processes with little to no human intervention (Merriam Webster, 2026). Two types of rewilding strategies were identified in Germany and Ukraine where the lynx is being reintroduced. Germany followed an “active” strategy where some human intervention was needed to reintroduce lynx, while Ukraine followed a “passive” strategy where no human intervention was needed. The purpose of this study is to determine how passive and active rewilding initiatives in Germany and Ukraine can both result in positive impacts on the environment.
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The Invisible Filipina Migrant Worker in Saudi Arabia: Analyzing the Perpetuation of Colonial Power Dynamics Through the Feminization of Migrant Care Labor
Allyson Collado
Every year, over a million Filipino women move overseas as domestic migrant workers, sending remittances that sustain almost a tenth of the Philippine economy. The Philippine government glorifies these Overseas Filipino Workers (OFWs) as heroesm, but they are still under-protected and treated as invisible, replaceable commodities in nations like Saudi Arabia.
This paper argues that the exploitation of Filipina migrant care workers is not just a side effect of neoliberal globalization, but a perpetuation of colonial power relations that is built into Philippine labor export policy and Saudi Arabia's legal architecture. -
Comparing GNGT1 Expression in Eye Tissue of Polymorphic Salamander Species Through Development
Fiona Coulbourne, Camila Cardozo, Macarena Machado, and Ruben Tovar
The effect of the environment on organisms and their adaptations is widely studied. When exposed to different environmental niches, phenotypic adaptation is observed even within species. Animals that live in dark cave environments show a loss of their eyesight, since this sense is no longer useful to keep. Previous research has studied salamanders of the clade Eurycea and compared gene expression to subterranean and surface phenotypes1. E.pterophila is observed to express these two phenotypes depending on its environment, either Preserve Cave (subterranean) or Comal Springs (surface). Subterranean variant shows reduced eye volume and assumes to have decreased eyesight. Utilizing RNASeq data, we compare gene expression within development of these two phenotypes to identify which genes are being over-expressed in each phenotype. GNGT1 is a gene that participates in rod formation. It is highly conserved gene in vertebrates that encodes the gamma subunit of transducin, allowing for eyesight perception in low light2,3. Observing the different expression patterns in each phenotype gives us a glimpse in eyesight loss and gene regulation through development.
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Investigating the endogenous & synthetic estrogens to the three estrogen receptor subtypes of teleost fish
Ann Cyril
Estrogen and the estrogen receptors are important biological and physiological processes. The various types of estrogen include estrone, estradiol and estriol. Estradiol’s main function is to maintain the reproductive system. Estrone’s main function is to develop the female's reproductive functions. Estriol’s main function is to aid the female's sexual developments but is on the weaker side. The fish, Atlantic Croaker, has three different estrogen receptors: ERα, ERβa, and ERβb. Based on the estrogen receptors, it appears that their binding affinities do differ in strength. Each estrogen receptor has different amino acids involved that could contribute to the difference in their binding affinities to estrogen, which will be explored more in depth.
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Texas Rangers & the Porvenir Massacre
Flavia Delgado
On January 28, 1918, in West Texas, the small village of Porvenir - now a ghost town - was the site of a deadly and unjustified act of violence. In the early morning hours, a group of Texas Rangers an U.S Army soliders killed 15 Mexican American men and boys. Prior to their deaths, the victims were disarmed and detained without legal justification and were executed without due process or the opportunity to defend themselves against unsubstantiated accusations.
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Using AI to predict Energy Expenditure in Lower Limb Prosthesis Users
Nelly Diaz and Siem Hadish
• Computer vision has evolved from simple image classification and object detection to analyzing human motion and biomechanics (1). • CNN’s are usually focused on image classification, but, in this case, we are not asking the model if a person is walking. • Many real-world problems require regression: Predicting a continuous number like energy expenditure of walking is a complex task. • It is essential for Prosthetists to understand energy expenditure of their prosthetic patients (2). • An amputee may use 20-30% more energy to walk. • In this project, we developed an AI model to analyze human motion and predict energy expenditure to improve prosthetic design.
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Fallen Light
Joshua Do
Lucifer is often portrayed in popular media as purely evil; however, this interpretation overlooks the more complex idea of gradual moral corruption through deception and pride. The purpose of Fallen Light is to explore how doubt, pride, and subtle deception can lead even a highly exalted being away from God over time.. The game emphasizes the internal struggle between obedience and self-exaltation rather than immediate rebellion, and the problems with Being overly prideful.
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From Stacks to Scholarship: A Legacy of the Academic Library (1968-2000)
Diane Duesterhoeft and Janet Ojinnaka
In 2027, St. Mary's University will celebrate the Dodransbicentennial (175th) anniversary of its founding.
In 2025, the Louis J. Blume Library celebrated the 25th anniversary of its renaming from the Academic Library. Here, we highlight some milestones from the library's history.More information is available here: https://lib.stmarytx.edu/tour/timeline
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The Impact of Stress on Dream Content
Tessa Duncan and Mason Trevino
• This research investigated how daily stress levels influence the intensity of dreams. The study aimed to clarify the relationship between stress and dream intensity, enhancing understanding of stress’s broader effects on mental health. • Building on Rush’s concept of a “goldilocks zone” in the stress scale, where moderate stress benefits well-being while too little or too much stress can cause harm (2024). The current study used the hallucination model of dreaming from Gillespie and Trakas (2024), which views dreams as vivid, perception-like experiences that can amplify emotions. Drawing on Gessert’s methods for measuring stress and nightmare frequency, stress is defined as the psychological and physiological reactions to uncontrollable events, and dreams as hallucination-like reflections of waking emotions (2023).
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The Effects of Low Stimulating Music vs. High Stimulating Music on Visual and Auditory Reflexes in Young Adults
Monabelle Elbayeh, Vania Galindo, Ria Modi, and Gianna Montelongo
This study investigates the effects of high-stimulating versus low-stimulating music exposure on human reflexes, specifically examining how different levels of auditory stimulation influence reaction time. Music is known to impact cognitive and motor performance, but its direct effect on reflex responses remains less understood. In this experiment, participants are exposed to high-stimulating music and low-stimulating music in separate trials, with reflexes measured before and after each condition using visual and auditory tests in the LabScribe program. It is hypothesized that after listening to high-stimulating music for five minutes, individuals will demonstrate shorter reaction times compared to after listening to low-stimulating music. This is because high-stimulating music is expected to increase attentiveness to stimuli, whereas low-stimulating music may promote relaxation and slower responsiveness. By comparing these conditions under controlled laboratory settings, this study aims to provide insight into how auditory stimulation affects reflexes and overall cognitive and motor performance.
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Effects of Tubulin-Binding Medications on Microplastic Uptake and Cyotoskeletal Functionality across Diverse Cell Types
Alejandra D. Favela Santos
• Microtubules are composed of of a- and b- tubulin heterodimers, vital for cell structure, shape, and intracellular transport • Microtubules are also useful as they separate chromosomes during cell division • Microplastics (< 5 mm) are considered a health threat and have been found throughout the whole body (1) o In several studies, microplastics have been correlated to higher rates cardiorespiratory issues, endocrine disruption, and cancer (1) • Tubulin-binding medications are widely used as chemotherapeutic agents as they are known for disrupting cell division and targeting tubulin (2,3) o In this study, these medications were used to determine whether microtubules play a role in microplastic uptake § Colchicine typically binds to tubulins and arrests polymerization and growth § Nocodazole disrupts polymerization and prevents spindle formation § Vinblastine inhibits microtubule assembly and disruptions miotic spindle formation.
• The purpose of this study was to determine if different concentrations of tubulin-binding medications affect microplastic uptake o C2C12, RAW 264.7, and MOVAS cell lines were used to evaluate whether these changes are cell type specific
If microtubule dynamics are disrupted, microplastic uptake can be affect in a concentration-dependent and cell type- specific manner. -
Does Habitat Predict Head Shape? A Comparative Geometric Morphometric Analysis of Eurycea spp.
Sarah Flores-Garza, Alexa Miner, and Gianna Montelongo
Subterranean environments impose strong selective pressures, including complete darkness and reliance on non-visual sensory systems. In Eurycea salamanders, these conditions are associated with traits such as reduced eyes and expanded head regions that improve sensory detection (Tovar et al., 2025). Subterranean species are often expected to share similar head shapes due to convergent evolution. However, not all species experience these pressures equally. Eurycea latitans is a polymorphic species that inhabits both surface and cave environments. Eurycea sp._NB is an obligate subterranean species, while Eurcyea sosorum is a surface species. This study tests whether habitat predicts head shape in Eurycea, or whether differences in the degree of subterranean specialization better explain variation in morphology by comparing a surface species (E. sos), a polymorphic species (E. lat), and an obligate subterranean species (E. sp._NB).
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