Files
Publication Date
Spring 2025
Keywords
Ewing sarcoma, genes, Cancer, cells
Description
Ewing sarcoma is an aggressive cancer that affects children & adolescents. Common treatments include surgery, radiation, and chemotherapy, yet individuals have a poor survival rate and often develop side effects from treatment, including fertility issues, secondary cancer, heart problems, and growth abnormalities.1SOX18 is a gene identified to aid in cell proliferation and cell differentiation, leading to the development of several cancers, such as gastric, bladder, and lung cancer.2,3 SOX18 resides in the JAK2/STAT3 pathway as a regulator, along with another gene named KIT that instigates the formation of the cell signaling pathway.4KIT is a transmembrane tyrosine kinase, which instigates cell growth, differentiation, and survival.5,6Thus far, no relationship has been stated between SOX18 and KIT. Due to shared presence in the same pathway, this project proposes that when KIT is knocked out, then EWS cells will have an increased expression of SOX18, leading to increased cell growth and proliferation.
Collection
Cell and Molecular Methods
Format
Medium
Lab report, poster
Size or Duration
15 pages
City
San Antonio
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Aragon, Samantha; Herrera, Cristina; Rodriguez, Felicity; Smith, Riley; and Shackleford, Terry, "Lab Rats" (2025). Cell and Molecular Methods. 3.
https://commons.stmarytx.edu/biostulab25/3
Included in
Biology Commons, Cell Biology Commons, Genetics and Genomics Commons
