"I NEED HELP!": Can ashwagandha reduce inflammation-driven oxidative stress without inducing cytotoxicity in macrophages?

Authors

• Caitlyn Pinaga, St. Mary's University

Files

Contributor

Segovia, Jesus (Faculty Mentor)

Digital Publisher

Digital Commons at St. Mary's University

Publication Date

Spring 2026

Keywords

Ashwagandha, Stress responses, Inflammation, Cytokines, Oxidative Stress markers, THP-1 macrophages

Description

Ashwagandha has been shown to reduce inflammation in humans by lowering pro-inflammatory cytokines and oxidative stress markers, helping regulate immune responses. It is commonly used to support conditions linked to chronic inflammation, such as stress-related disorders, arthritis, and metabolic imbalance. THP-1 macrophages are a part of the body's immune response to inflammation. While they produce a lot of different responses to inflammation, one of them is the production of Reactive Oxygen Species (ROS). N-acetylcysteine (NAC) is established to be a powerful antioxidant and is used as a positive control. My study aims to understand how ashwagandha, a popular supplement, affects the production of ROS in macrophages during an inflammation response.

Format

PDF

Size

1 poster

City

San Antonio, Texas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.