Minimal Anti-Cancer Effects of Mushroom-Derived Compounds Hispidin and Chaga Extract on Ewing Sarcoma Cells

Authors

Jordan Cosgrove, St Mary's UniversityFollow
Fiona Coulbourne, St Mary's UniversityFollow
Iris Reyna, St Mary's UniversityFollow
Giselle Serna-Flores, St Mary's UniversityFollow
Terry Jo Shackleford, St Mary's UniversityFollow

Files

Publication Date

Spring 5-13-2025

Keywords

Cancer, Ewing Sarcoma, Hispidin, Chaga, Incucyte

Description

Ewing sarcoma is a rare and aggressive cancer of adolescents and young adults driven by the EWSR1–FLI1 gene fusion. Standard treatments include chemotherapy, surgery, and radiation, though survival rates remain low. Natural compounds such as hispidin, derived from fungi, and Chaga mushroom extract have shown potential anti-cancer effects by disrupting cell cycle progression and promoting apoptosis in other cancer models. In this study, we tested the effects of hispidin and Chaga extract on Ewing sarcoma cells to evaluate their ability to suppress cell growth and identify potential therapeutic benefits.

Collection

Cell and Molecular Methods

Format

pdf

Medium

Lab report, poster

Size or Duration

15

City

San Antonio

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Cosgrove, Jordan; Coulbourne, Fiona; Reyna, Iris; Serna-Flores, Giselle; and Shackleford, Terry Jo, "Minimal Anti-Cancer Effects of Mushroom-Derived Compounds Hispidin and Chaga Extract on Ewing Sarcoma Cells" (2025). Cell and Molecular Methods. 4.
https://commons.stmarytx.edu/biostulab25/4