Synthesis and Characterization of Metal Complexes of Oxindole-Based β-lactams

Authors

• Kenya Rosas, St. Mary's University
• Erick Morales Orrante, St. Mary's University
• Carlos Sifuentes, St. Mary's University
• Alexsei Nazarov

Files

Contributor

Adelani, Pius (Faculty Mentor)

Digital Publisher

Digital Commons at St. Mary's

Publication Date

Spring 2026

Keywords

Antibiotics, Organic Chemistry, Inorganic Chemistry, Ugi reaction

Description

• β-lactams are essential structural components of many antibiotics and widely studied due to their biological importance and synthetic versatility.
• The Ugi reaction is a multicomponent reaction, involving a primary amine, carboxylic acid, isocyanide, and an aldehyde or a ketone, that rapidly generates α-acetamido carboxamide derivatives (Ugi adducts).
• The synthesis and characterization of four oxindole-based β-lactam derivatives:
  • 1-Benzyl-N-(tert-butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3-carboxamide (4a).
  • N-(tert-butyl)-2-oxo-3-(2-oxoazetidin-1-yl)-1-phenylindol-3-carboxamide (4ab).
  • N-(tert-Butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3-carboxamide (4d).
  • N-(tert-butyl)-1-methyl-2-oxo-3-(2-oxoazetidin-1-yl)indol-3-carboxamide (4e).
• The coordination of the four Ugi adducts with Cu (II) and Ni (II) at different pH points to enhance their stability and improve biological activity.

Format

PDF

Size

1 poster

City

San Antonio, Texas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.