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Contributor
Segovia, Jesus (Faculty Mentor)
Digital Publisher
Digital Commons at St. Mary's
Publication Date
Spring 2026
Keywords
Community-Acquired Respiratory Distress Syndrome (CARDS) toxin, Respiratory infections
Description
Mycoplasma pneumoniae CARDS toxin induces cytotoxicity and inflammation in lung epithelial cells²·¹⁰·¹¹, while hyperglycemia independently elevates ROS and disrupts fibroblast repair¹·⁵·⁸, contributing to the heightened respiratory infection severity seen in diabetic patients¹. However, the interaction between hyperglycemic conditions and CARDS toxin-induced lung injury remains unexplored.
This study investigates how increasing high-glucose (HG) pre-conditioning modifies CARDS toxin-induced injury and recovery in A549⁶ and IMR-90⁷ cells compared to normal glucose (NG ≈ 5mM) controls. We hypothesized that increasing glucose pre-conditioning concentrations would produce a dose-dependent increase in CARDS toxin-induced oxidative stress¹² and inflammatory cytokine production¹⁵ in IMR-90 and A549 compared with normal glucose controls. We further hypothesized that antioxidant and anti-fibrotic recovery treatments would partially restore viability⁴·¹³and reduce cytokine release across the glucose concentrations.
Format
Size
1 poster
City
San Antonio, Texas
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Included in
Bacterial Infections and Mycoses Commons, Infectious Disease Commons, Medical Microbiology Commons, Pulmonology Commons, Respiratory Tract Diseases Commons