The Effects of Mycoplasma pneumoniae CARDS toxin on M2 Macrophage Polarization and Formation

Authors

• Ria Modi, St. Mary's University

Files

Contributor

Segovia, Jesus (Faculty Mentor); St. Mary's University Department of Biological Sciences

Digital Publisher

Digital Commons at St. Mary's University

Publication Date

Spring 2026

Keywords

Mycoplasma Pneumoniae, Community-acquired respiratory distress syndrome (CARDS), inflammation, Lung diseases

Description

Macrophages are key cells of the innate immune system, playing essential roles in host defense, tissue homeostasis, and inflammation. Depending on stimuli, macrophages can polarize into distinct functional phenotypes, characterized as classically activated (M1) or alternatively activated (M2) macrophages. M2 macrophages are associated specifically with anti-inflammatory responses, tissue repair, and immune regulation. They contribute to wound healing and can regulate host responses during infection. Community-acquired respiratory distress syndrome (CARDS) toxin, a key virulence factor of Mycoplasma pneumoniae, plays a role in altering host immune responses, but its impact on M2 macrophage function and polarization remains unclear.

Format

pdf

Size

1 poster

City

San Antonio, Texas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.