Spectroscopic and electrochemical properties of ugi adducts of Isatin

Authors

Callah Preti, St. Mary's University
Erick Y. Morales Orrante, St. Mary's University

Files

Contributor

Dr. Pius Adelani

Digital Publisher

Digital Commons at St. Mary's University

Publication Date

Spring 2025

Keywords

antibiotics; antibacterial

Description

• β-lactams are essential structural components of many antibiotics and widely studied due to their biological importance and synthetic versatility.

• The Ugi reaction is a multicomponent reaction involving: • Aldehyde, primary amine, carboxylic acid, and isocyanide.

• Rapidly generates α-acetamido carboxamide derivatives (Ugi adducts). • The study focuses on the synthesis and characterization of two oxindole-based β-lactam derivatives:

• 1-Benzyl-N-(tert-butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3- carboxamide (4a).

• N-(tert-Butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3- carboxamide (4d).

• Characterization methods included IR Spectroscopy, UV-Visible Spectroscopy, and X-Ray Crystallography.

• Future work will investigate metal complexation to enhance β-lactam stability, alter electronic properties, and improve biological activity

Format

pdf

Size

1 page

City

San Antonio, Texas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.