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Contributor
Benjamin T. Enslow; UT Health San Antonio
Digital Publisher
Digital Commons at St. Mary's University
Publication Date
Spring 2025
Description
• Maternal obesity is an increasingly prevalent condition worldwide that has been associated with adverse outcomes in offspring, including higher propensity to infection and elevated risk of immune-related disorders like asthma and allergies 1 .
• Breast milk contains a wide variety of immunological components that are essential for neonatal immune development. Among these, it contains immunoglobin G (IgG) immune complexes, which are formed by IgG bound to specific antigens2 .
• These immune complexes have been suggested to play a crucial role in antigen-specific immune response in breastfed infants3 , increasing oral tolerance and asthma prevention 4 .
• Colostrum, the first milk produced after birth, is especially rich in immune components and plays a fundamental role in the immune system development of the infant 1 .
• The purpose of this study is to investigate the impact of maternal obesity on this immunological process by measuring antigen-bound IgG immune complexes in colostrum and plasma samples from a cohort of 9 mothers with BMI between 18.5-25 or >30 kg/m2.
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1 page
City
San Antonio, Texas
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
