Synthesis and Characterization of Ugi Adducts of Isatin

Authors

Monabelle Elbayeh, St. Mary's University

Files

Digital Publisher

Digital Commons at St. Mary's University

Publication Date

Spring 2024

Contributor

Shackleford, Terry (Faculty Mentor)

Keywords

Chemistry, Chemical Synthetization, Ugi, Isatin

Description

Known as the deadliest disease in the modern age, 1 in 3 people will have cancer in their lifetime (Chakraborty, Sajib & Rahman Taibur, 2012). However, despite this beyond-belief statistic and the significant and continuous amount of research done in hopes to cure cancer, cancer still remains. What makes cancer so difficult to cure comes from an arrangement of elements from the difficult targeting of cancer stem cells to the metastasis of cancer, but one that is especially touched on in this study is the lack of cancer epigenetic profiling lifetime (Chakraborty, Sajib & Rahman Taibur, 2012).

Focusing on ES8 and JR1 cells from the aggressive bone and soft-tissue cancer of Ewing sarcoma, this study observes and analyzes the effects of SOX18 overexpression and how the gene’s expression could affect the growth of tumors. If left without systemic therapy, Ewing sarcoma causes over 90% of patients to die from disseminated disease. Hence, systemic tumor control poses the main therapeutic challenge that the study of specific gene expression could help overcome (Bauer, Sebastian, et al., 2021).

Lastly, SOX genes have been shown to be essential for stem cell renewal, reprogramming, and homeostasis (Zhang, Shizhen, et al., 2020). Furthermore, overexpression of the gene has been associated with poor cancer patient survival rates, as it promotes proliferation, survival, invasion/metastasis, cancer stemness, and drug resistance (Zhang, Shizhen, et al., 2020). Nonetheless, greater research is still needed to further understand its involvement in human cancers. Thus, calling for our further research on the subject through cellular proliferation, colony formation, and cell invasion assays. Along with also Western Block experiments.

Format

pdf

Size

1 page

City

San Antonio, Texas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.