Maria Chiara Cossio - 2023

Maria Chiara Cossio - 2023


Publication Date


Digital Publisher

Digital Commons at St. Mary's University


Higher Education


Action potential, threshold, input current, firing rate, alpha synapse


McNair Scholars Symposium




When a neuron receives a stimulus it will become depolarized and reach a certain threshold producing an action potential, which will fire, sending the electrical signal down the axon. In order to analyze the behavior of these neural systems and how they can be affected based on their input current (I.C.), a model called Leaky Integrate-and-fire neuron (LIF) was used. In this simple mathematical model, a simulation was run where the neuron's threshold was set to 4mV, and a set of 7 input currents was established; (I.C.= 0.1, 0.2, 0.3 0.4, 0.5, 0.6, 0.7), each was measured with the same stimulus duration, 500msec. Two different stimuli were sent from the alpha synapses, first with a value of α=1 and the second of α=0.5 to the neuron, if an action potential is generated it will produce a peak above 4mv, which is counted and then divided by the time in milliseconds. The firing rate (F.R.) for the first stimulus was (F.R.=0, 0, 0.016, 0.024, 0.032, 0.04, 0.048) respectively, while the second one was (F.R.=0, 0, 0, 0, 0, 0.002, 0.006) respectively. Furthermore, the results from the experimental data collected and analyzed demonstrate a clear correlation between firing rate and input current. This suggests that the action potential occurs more frequently if there is a higher input current and higher alpha synapses.


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Digital Commons at St. Mary's University

Maria Chiara Cossio - 2023