Maria Chiara Cossio - 2023
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Publication Date
11-10-2023
Digital Publisher
Digital Commons at St. Mary's University
Disciplines
Higher Education
Keywords
Action potential, threshold, input current, firing rate, alpha synapse
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Collection
McNair Scholars Symposium
Format
MOV
Description
When a neuron receives a stimulus it will become depolarized and reach a certain threshold producing an action potential, which will fire, sending the electrical signal down the axon. In order to analyze the behavior of these neural systems and how they can be affected based on their input current (I.C.), a model called Leaky Integrate-and-fire neuron (LIF) was used. In this simple mathematical model, a simulation was run where the neuron's threshold was set to 4mV, and a set of 7 input currents was established; (I.C.= 0.1, 0.2, 0.3 0.4, 0.5, 0.6, 0.7), each was measured with the same stimulus duration, 500msec. Two different stimuli were sent from the alpha synapses, first with a value of α=1 and the second of α=0.5 to the neuron, if an action potential is generated it will produce a peak above 4mv, which is counted and then divided by the time in milliseconds. The firing rate (F.R.) for the first stimulus was (F.R.=0, 0, 0.016, 0.024, 0.032, 0.04, 0.048) respectively, while the second one was (F.R.=0, 0, 0, 0, 0, 0.002, 0.006) respectively. Furthermore, the results from the experimental data collected and analyzed demonstrate a clear correlation between firing rate and input current. This suggests that the action potential occurs more frequently if there is a higher input current and higher alpha synapses.
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Publisher
Digital Commons at St. Mary's University