Di-butyl Phthalate and Polystyrene Microplastic Mixture Exposure Results in Decreased Lifespan and Reproductive Toxicity in C. elegans

Di-butyl Phthalate and Polystyrene Microplastic Mixture Exposure Results in Decreased Lifespan and Reproductive Toxicity in C. elegans

Chiara Angelyn O. Maldonado, St. Mary's University
Paola C. Garcia, St. Mary's University
Maria F. Gamez, St. Mary's University
David Mares, St. Mary's University

Description

Microplastics (MPs, >5mm1 ) are an environmental pollutant that poses health risks to humans.

▪ Effects of microplastics include oxidative stress, metabolic disorders, immune responses, neurotoxicity, and reproductive issues2-3 .

▪ Phthalates are widely used as plasticizers, in commercial products and are widely considered endocrine disruptors that harm the reproductive system and development4-5 .

▪ We use the C. elegans model to investigate the effect of polystyrene (PS) MP and Di-butyl phthalate (DBP) exposure on fertility, development and lifespan.